Adverse Childhood Experiences, DNA Methylation, and Depressive Symptoms in Black Pregnant Women
This study provides evidence that DNAm partially mediated the association of ACEs and depressive symptoms during pregnancy among Black pregnant women. Understanding the molecular pathways underlying the mediating effect of ACEs on depressive symptoms among Black pregnant women can illuminate biological markers that help identify and treat pregnant women who are at an increased risk for depression following childhood trauma.
Authors
- Marvin A. Solberg (ORCID: https://orcid.org/0000-0001-8003-4347)
- Carmen Giurgescu (ORCID: https://orcid.org/0000-0002-4577-3184)
- Dawn P. Misra (ORCID: https://orcid.org/0000-0002-0093-823X)
- Xiaoyu Liang (ORCID: https://orcid.org/0000-0001-7796-2441)
- Alexandra Nowak (ORCID: https://orcid.org/0000-0003-3457-593X)
- Fabiola Magaña
Institutions
- University of Central Florida (US)
- Loyola University Chicago (US)
- University of Michigan (US)
- Michigan State University (US)
Publication Details
- Journal
- Epigenomes
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3390/epigenomes9040048
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 0.00