Platelet-Rich Plasma in Split-Thickness Skin Graft Donor Sites: A Narrative Review of Healing Outcomes and Pain Reduction

Split-thickness skin autografts are the most widely used strategy for the treatment of large coverage defects secondary to trauma, burns, oncologic resections, and ulcers. However, donor site management remains a challenge, as it is associated with considerable morbidity due to pain, bleeding, pruritus, and delayed healing, often greater than in the grafted area. In this scenario, platelet-rich plasma (PRP) has gained popularity as an adjuvant therapy, with favorable results in reducing these complications. The objective of this study was to narratively review the scientific literature on the use of PRP in donor sites of split-thickness skin grafts (STSGs), with emphasis on pain control and healing outcomes. A narrative literature review was conducted, selecting key publications indexed in PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), and Elsevier. The collected information included mechanisms of action, application techniques, clinical outcomes, and pain reduction. Additionally, institutional experience and certain relevant technical aspects are discussed. PRP accelerates epithelialization, reduces postoperative pain, decreases complications at donor sites, and improves healing quality, thereby promoting faster recovery and lower morbidity. These benefits establish it as a useful and accessible therapeutic option in this clinical setting.