MET Overexpression Is Associated with Superior Immunotherapy Benefit in Advanced Non-Small Cell Lung Cancer
This real-world study suggests that MET overexpression, as assessed by IHC, is associated with better survival in advanced NSCLC patients treated with ICIs, independent of PD-L1 level. These results suggest the potential of MET expression as a predictive marker for ICI efficacy in advanced NSCLC patients and support the combination of MET-targeted agents with anti-PD1/PD-L1 ICIs as a promising strategy for NSCLC patients with MET overexpression.
Authors
- Haniel Alves Araújo (ORCID: https://orcid.org/0000-0002-7980-0515)
- Jia Wu (ORCID: https://orcid.org/0000-0001-8392-8338)
- Xiuning Le (ORCID: https://orcid.org/0000-0002-8554-1185)
- Wei Lü (ORCID: https://orcid.org/0000-0003-4159-3861)
- Frank V. Fossella
- Don L. Gibbons (ORCID: https://orcid.org/0000-0003-2362-3094)
- Khaja Khan
- Bingnan Zhang (ORCID: https://orcid.org/0000-0002-1821-6243)
- Marcelo Vailati Negrao (ORCID: https://orcid.org/0000-0001-8938-6699)
- Elliana Young
- Ignacio I. Wistuba (ORCID: https://orcid.org/0000-0003-3365-6340)
- Lingzhi Hong (ORCID: https://orcid.org/0000-0001-6553-3279)
- Waree Rinsurongkawong (ORCID: https://orcid.org/0000-0002-8750-7562)
- Mehmet Altan (ORCID: https://orcid.org/0000-0001-9229-156X)
- Pedro Rocha (ORCID: https://orcid.org/0000-0003-3221-7354)
- John Victor Heymach (ORCID: https://orcid.org/0000-0001-9068-8942)
- Ferdinandos Skoulidis (ORCID: https://orcid.org/0000-0002-4676-4503)
- Ara Asadur Vaporciyan (ORCID: https://orcid.org/0000-0002-2060-3584)
- Hai T. Tran (ORCID: https://orcid.org/0000-0003-4065-9355)
- Anne S. Tsao (ORCID: https://orcid.org/0000-0003-0505-6639)
- Carl M. Gay (ORCID: https://orcid.org/0000-0002-4907-0718)
- Tina Cascone (ORCID: https://orcid.org/0000-0003-3008-5407)
- Lauren A. Byers (ORCID: https://orcid.org/0000-0002-0780-2677)
- Yasir Y. Elamin (ORCID: https://orcid.org/0000-0002-5312-909X)
- George R. Blumenschein (ORCID: https://orcid.org/0000-0002-9606-8194)
- Luisa M. Solis Soto (ORCID: https://orcid.org/0000-0002-1253-630X)
- Natalie I. Vokes (ORCID: https://orcid.org/0000-0002-3766-5335)
- Jianling Zhou
- Claudio A. Arrechedera (ORCID: https://orcid.org/0009-0001-5358-480X)
- Jianjun Zhang (ORCID: https://orcid.org/0000-0001-7872-3477)
- J. Jack Lee (ORCID: https://orcid.org/0000-0001-5469-9214)
- Hui Li (ORCID: https://orcid.org/0000-0003-3139-2898)
- Rafael Bach
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Hospital Del Mar (ES)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3390/cancers17233801
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00