Prognostic significance of CD44s expression in oral squamous cell carcinoma: An immuno-histo-chemical analysis
Oral squamous cell carcinoma (OSCC) is a common malignancy with a poor prognosis, highlighting the need for reliable molecular biomarkers. CD44s, a cell adhesion molecule, has been implicated in tumor progression, but its prognostic role in OSCC is unclear. This retrospective study evaluated CD44s expression in 50 OSCC cases using immunohistochemistry and an immunoreactive scoring system. High CD44s expression significantly correlated with advanced stage, lymph node metastasis and poor histological grade. CD44s overexpression may serve as a prognostic biomarker to identify high-risk OSCC patients requiring aggressive therapy.
Authors
- Sandeep Singh Sidhu (ORCID: https://orcid.org/0000-0002-9194-2110)
- Arpit Sharma (ORCID: https://orcid.org/0000-0001-8238-624X)
- Harinder R. Singh (ORCID: https://orcid.org/0000-0003-3164-2586)
- Arun Bhardwaj
- Mamta Sharma
- Souvik Rana
Institutions
- Bhabha Hospital (IN)
- Swami Devi Dyal Hospital and Dental College (IN)
- National Institute of Pharmaceutical Education and Research (IN)
- Rajasthan Dental College and Hospital (IN)
Publication Details
- Journal
- Bioinformation
- Published
- 2025-11-15
- DOI
- https://doi.org/10.6026/973206300214060
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00