Closing the evidence loop—membrane-lipid homeostasis and vesicular transport link DEHP exposure to endometriosis

This study establishes a comprehensive workflow spanning from chemical exposure identification to target discovery, disease network mapping, interpretable computational modeling, and structural/dynamical validation. We propose a DEHP-Ems regulatory framework underpinned by lipid metabolism, vesicular trafficking, and detoxification pathways. The resulting seven-gene signature provides a clinically applicable panel for diagnostic stratification and highlights potential therapeutic entry points, particularly along the HMGCR axis and via SLC1A5-mediated glutamine uptake. These findings lay the groundwork for future mechanistic studies in primary cell systems, organoid models, in vivo experiments, and prospective clinical validation.