Salivary pH, uric acid and C - reactive protein in conventional versus chitosan-nanoparticle denture wearers

Edentulous patients wearing complete dentures often face poor denture hygiene and mucosal inflammation. Incorporating antimicrobial agents such as chitosan nanoparticles (CNPs) into dentures may improve the oral environment. In this study, salivary pH, uric acid and C-reactive protein (CRP) were compared between conventional dentures and CNP-incorporated dentures in edentulous patients. After one month of use, CNP\ dentures significantly increased salivary pH and uric acid while showing a non-significant decrease in CRP. Thus, we show that CNP incorporation enhances oral health by improving salivary parameters and reducing inflammatory responses.