Hematological and gastroprotective effects of Madhulai Manappagu syrup in indomethacin-induced gastric ulcer animal models

Gastric ulcer is a major gastrointestinal disorder with high global prevalence. <i>Madhulai Manappagu</i>, a Siddha herbal syrup preparation, is traditionally prescribed for gastric ailments, is of interest to evaluate the gastroprotective and hematological effects of Madhulai Manappagu in indomethacin-induced gastric ulcer in Wistar albino rats. Hematological parameters including hemoglobin, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, packed cell volume, platelet count and serum iron were determined using standard protocols and for anti-ulcer evaluation, <i>Madhulai Manappagu</i> was given orally at 500 and 1000 mg/kg body weight. Treatment with <i>Madhulai Manappagu</i> significantly (p < 0.00001) and dose-dependently improved hematological indices and serum iron levels in ulcerated rats compared to positive control. <i>Madhulai Manappagu</i> demonstrates significant gastroprotective and hematological benefits in indomethacin-induced ulcerated rats hence show its potential as a safe plant-based therapeutic option for gastric ulcer, particularly in bleeding-associated conditions.