Cephalosporin allergy: R1 side-chain and penicillin cross-reactivity patterns in an Australian cohort
R1 side-chain groups explained most test outcomes in this study. However, some positive penicillin skin testing results were identified without a history of penicillin allergy. Future research investigating the safety of supervised graded penicillin challenges in cephalosporin-allergic patients is needed.
Authors
- Patricia Martínez (ORCID: https://orcid.org/0000-0003-4311-2945)
- Brittany Stevenson (ORCID: https://orcid.org/0000-0002-4002-1055)
- Elizabeth Klinken (ORCID: https://orcid.org/0000-0001-7142-2583)
- Michelle Trevenen (ORCID: https://orcid.org/0000-0002-0614-8319)
- Jack Bourke (ORCID: https://orcid.org/0009-0000-0378-8276)
- Michaela Lucas (ORCID: https://orcid.org/0000-0001-8881-9990)
Institutions
- The University of Western Australia (AU)
- Fiona Stanley Hospital (AU)
- Sir Charles Gairdner Hospital (AU)
- Pathwest Laboratory Medicine (AU)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.jacig.2025.100583
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00