Prevalence, associated factors, and pharmacotherapy of hypertensive disorders among parturients in Bono Region of Ghana: An analytical cross-sectional study.

The burden of hypertensive disorders in pregnancy (HDP) in remote areas of Ghana remains understudied. This analytical cross sectional study investigated the prevalence, associated factors, and pharmacotherapy of HDPs in the Bono Region of Ghana. Data from labor registers of nine public hospitals, from January to December 2021, were analyzed. Guidelines for administering magnesium sulfate and antihypertensives were assessed. Associations were examined using chi-square and multivariable binomial regression with odds ratios at 95% confidence intervals. P ≤ 0.05 was statistically significant. Of 16,206 deliveries, 711 parturients (4.4%) were complicated by HDPs. Non-severe pre-eclampsia (30.5%) and gestational hypertension (28.0%) were most frequent, while eclampsia (6.2%) and superimposed pre-eclampsia (1.7%) were less common. Maternal age 15-25 years (cOR = 2.43), unemployment (cOR = 2.14), primigravidity (cOR = 2.88), and primiparity (cOR = 2.39) were significantly associated with pre eclampsia/eclampsia. After adjustment for confounding variables, primiparity remained borderline significant (aOR = 1.83; p = 0.05). Oral nifedipine and intravenous hydralazine were the primary antihypertensive therapies. Magnesium sulfate was universally administered using the Pritchard regimen, though product concentrations for intramuscular use varied slightly. Findings highlight the need to standardize magnesium sulfate formulations to optimize intramuscular dosing and enhance treatment consistency in lower-level facilities managing HDPs.