Mechanism of Atractylodis Rhizoma in improving cognitive dysfunction in Alzheimer's disease by regulating the cAMP/CREB/BDNF pathway
EEAR mitigates AD pathogenesis by directly targeting hippocampal neuroinflammation and potently activating cAMP signaling, establishing its potential as a multi-target therapeutic candidate and providing a scientific basis for traditional medicine-derived AD interventions.
Authors
- Zhenqiang Zhang (ORCID: https://orcid.org/0000-0002-1736-1289)
- Linyu Yu (ORCID: https://orcid.org/0000-0002-7167-0410)
- Yunfang Su
- Junying Song (ORCID: https://orcid.org/0000-0002-9816-4454)
- Zhishen Xie (ORCID: https://orcid.org/0000-0002-0008-9637)
- Yinan Zhao (ORCID: https://orcid.org/0000-0002-9501-4725)
- Pan Wang (ORCID: https://orcid.org/0000-0002-9779-1878)
- Huifen Ma
- Xinlin Xu
- Yilong Hu (ORCID: https://orcid.org/0009-0008-8078-0428)
Institutions
- Innovation Team (China) (HK)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.intimp.2025.115923
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00