Factors influencing the removal of protein-bound uremic toxins in hemodiafiltration
The clearance of PBUTs is primarily diffusive. Enhancing all variables related to this physical principle will improve the elimination of these toxins. Postdilution HDF with high convective volume slightly increases this clearance. However, the results remain insufficient given the high toxicity of these molecules. New strategies, such as the use of adsorptive membranes and competitive molecules, are needed to optimize their removal and reduce the negative cardiovascular impact in hemodialysis patients.
Authors
- Elena Cuadrado‐Payán (ORCID: https://orcid.org/0000-0003-2412-6911)
- José Jesús Broseta (ORCID: https://orcid.org/0000-0002-4559-9083)
- Gregori Casals (ORCID: https://orcid.org/0000-0002-3271-1371)
- Lida Rodas (ORCID: https://orcid.org/0000-0002-5071-6862)
- Francisco Maduell (ORCID: https://orcid.org/0000-0002-1673-0353)
- Néstor Fontseré (ORCID: https://orcid.org/0000-0002-3190-9319)
- Víctor Joaquín Escudero-Saiz (ORCID: https://orcid.org/0000-0003-0411-207X)
- María Rodríguez‐García (ORCID: https://orcid.org/0000-0003-2015-7286)
Institutions
- Hospital Clínic de Barcelona (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Nefrología (English Edition)
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.nefroe.2025.501391
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00