Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation
Collectively, this study links the detection of fecal S100A9 dimers with clinical and endoscopic disease activity in IBD and identifies inflammatory actions of S100A8 and S100A9 homodimers in the intestine. Our findings pave the way for novel diagnostic and therapeutic approaches in patients with inflammatory diseases of the intestine.
Authors
- Günter Weiß (ORCID: https://orcid.org/0000-0003-0709-2158)
- Qitao Ran (ORCID: https://orcid.org/0000-0002-2127-8349)
- Niloofar Nemati (ORCID: https://orcid.org/0009-0004-5923-2073)
- Sabine Scholl‐Bürgi (ORCID: https://orcid.org/0000-0002-2529-4231)
- Peter Willeit (ORCID: https://orcid.org/0000-0002-1866-7159)
- Felix Grabherr (ORCID: https://orcid.org/0000-0001-5731-8253)
- Victoria Klepsch (ORCID: https://orcid.org/0000-0003-4146-4664)
- Bettina Sarg (ORCID: https://orcid.org/0000-0002-4785-8739)
- A Kozsar
- Petra Bächer (ORCID: https://orcid.org/0000-0003-4264-6451)
- Katja Vouk
- A Weichberger
- Denise Aldrian (ORCID: https://orcid.org/0000-0002-6787-4939)
- Christina Plattner (ORCID: https://orcid.org/0000-0002-3217-3278)
- Felix Sommer (ORCID: https://orcid.org/0000-0002-6545-3487)
- Gottfried Baier (ORCID: https://orcid.org/0000-0002-2085-8325)
- Lina Welz (ORCID: https://orcid.org/0009-0008-3779-623X)
- Julian Schwärzler (ORCID: https://orcid.org/0000-0001-9939-7324)
- Daniela Karall (ORCID: https://orcid.org/0000-0002-4846-1047)
- Ivan Tancevski (ORCID: https://orcid.org/0000-0001-5116-8960)
- Georg Friedrich Vogel (ORCID: https://orcid.org/0000-0002-2515-4490)
- Almina Jukic (ORCID: https://orcid.org/0000-0001-8201-1376)
- Kerstin Siegmund (ORCID: https://orcid.org/0000-0002-3654-1170)
- Arthur Kaser (ORCID: https://orcid.org/0000-0003-1419-3344)
- Philip Rosenstiel (ORCID: https://orcid.org/0000-0002-9692-8828)
- Dietmar Rieder (ORCID: https://orcid.org/0000-0003-1754-690X)
- Andreas Zollner (ORCID: https://orcid.org/0000-0001-6095-068X)
- Konrad Aden (ORCID: https://orcid.org/0000-0003-3482-7316)
- Richard Hilbe (ORCID: https://orcid.org/0000-0001-9987-109X)
- Latifa Bakiri (ORCID: https://orcid.org/0000-0002-6300-2420)
- Valentin Marteau (ORCID: https://orcid.org/0000-0002-3667-1653)
- Arnau Vich Vila (ORCID: https://orcid.org/0000-0003-4691-5583)
- Thomas Müller (ORCID: https://orcid.org/0000-0001-8908-5589)
- Richard S. Blumberg (ORCID: https://orcid.org/0000-0002-4622-825X)
- Klaus Faserl (ORCID: https://orcid.org/0000-0003-1646-3256)
- Lisa Mayr (ORCID: https://orcid.org/0000-0003-0869-242X)
- Moritz Meyer
- Robert Koch
- Alexandra Pfister
- Stefan Schreiber
- Patrizia Moser
- Luis Zundel
Institutions
- Brigham and Women's Hospital (US)
- University Medical Center Groningen (NL)
- Harvard University (US)
- Innsbruck Medical University (AT)
- The University of Texas at San Antonio Health Science Center (US)
- Universität Innsbruck (AT)
- University of Cambridge (GB)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Innsbruck (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1053/j.gastro.2025.08.040
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Humboldt-Universität zu Berlin
- Freie Universität Berlin
- Leibniz-Gemeinschaft