Clinicopathological features differentiating Castleman Disease from IgG4-related ophthalmic disease, a 10 years retrospective study

Significant differences in pathology and imaging exist between IgG4-ROD and CD. IgG4-ROD is characterized by an IgG4+/IgG+ plasma cell ratio exceeding 40% and extensive fibrosis. Imaging predominantly reveals nondestructive fibrotic foci, reflecting the chronic inflammatory fibroproliferative nature of the disease. Conversely, CD exhibits higher local invasiveness and lower cellular proliferative activity.