Functional Genomics Link REST to Endothelial Plasticity and Atherosclerosis
In summary, our data reveal the novel role of REST as a repressor in endothelial cells that functions to constitutively inhibit endothelial-to-mesenchymal transition and protect against atherosclerosis.
Authors
- Marios Arvanitis (ORCID: https://orcid.org/0000-0001-8046-6123)
- Roujin An (ORCID: https://orcid.org/0009-0006-6689-9671)
- Andrew S. McCallion (ORCID: https://orcid.org/0000-0002-0016-8466)
- Pablo Toledano-Sanz (ORCID: https://orcid.org/0000-0002-8347-2227)
- Charles J. Lowenstein (ORCID: https://orcid.org/0000-0003-0485-7514)
- Nunzio Alcharani (ORCID: https://orcid.org/0000-0002-9477-7712)
- Quanyi Zhao (ORCID: https://orcid.org/0000-0001-9849-4528)
- Thomas Quertermous (ORCID: https://orcid.org/0000-0002-7645-9067)
- William O. Osburn (ORCID: https://orcid.org/0000-0002-7472-3805)
- Alexis Battle (ORCID: https://orcid.org/0000-0002-5287-627X)
- Arianna Scalco (ORCID: https://orcid.org/0000-0002-0510-6045)
- Paula Reventún (ORCID: https://orcid.org/0000-0002-6221-8780)
- María Delgado-Marín (ORCID: https://orcid.org/0000-0002-3078-7321)
- Maria Viskadourou (ORCID: https://orcid.org/0009-0004-3883-8471)
- Sharjeel A. Chaudhry (ORCID: https://orcid.org/0000-0001-8701-3979)
- Abigail Fennell (ORCID: https://orcid.org/0009-0007-7621-7993)
Institutions
- Johns Hopkins University (US)
- Palo Alto University (US)
- Universidad de Alcalá (ES)
- Johns Hopkins Medicine (US)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- The Ohio State University (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1161/circresaha.125.326628
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00