Mesenchymal stem cells’ exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats
These findings demonstrate that BMSC-Exos alleviate chronic visceral pain and comorbid anxiety in IBS rats, likely through Nrf-2/HO-1-mediated oxidative stress reduction in spinal neurons. These results highlight BMSC-Exos as a promising acellular therapeutic strategy for IBS, offering potential applications for this debilitating disorder.
Authors
- Yongxiao Liu
- Yixia Zhu (ORCID: https://orcid.org/0000-0001-6342-5266)
- X Chen (ORCID: https://orcid.org/0009-0001-9864-8707)
- Xiaohua Lian (ORCID: https://orcid.org/0000-0002-3682-2087)
- Chun Lin (ORCID: https://orcid.org/0000-0002-7141-2446)
- Libin Liu (ORCID: https://orcid.org/0000-0002-0352-3865)
- Minjie Li (ORCID: https://orcid.org/0000-0003-0616-4826)
- Lü Jin (ORCID: https://orcid.org/0000-0001-7933-0309)
- Jianqing Lin (ORCID: https://orcid.org/0009-0008-5020-0162)
- Jinchao You
- Ying Lai
Institutions
- Fujian Medical University (CN)
- Ningde Normal University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- PAIN Reports
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1097/pr9.0000000000001372
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00