17β-Estradiol Improves Liver Function in T2DMNAFLD Mice via PGC-1α/ERRα Axis Activation While Preserving Cholestatic Safety

This study demonstrates that E2 alleviates metabolic dysfunction and hepatic injury in T2DM-NAFLD mice by activating the PGC-1α/ERRα axis, while preserving cholestatic safety, as evidenced by non-concerted ALP/TBA/TBil changes within reference limits. PGC-1α is essential for mediating these effects, highlighting the PGC-1α/ERRα pathway as a promising therapeutic target for metabolic liver disease.