Systems biology and experimental validation indicate DDIT4, FOXO1, and STAT3 as shared key genes linking osteoporosis and sarcopenia
This study uncovers key molecular links between osteoporosis and sarcopenia, highlighting DDIT4, FOXO1, and STAT3 as shared biomarkers. The findings provide novel insights into their common pathophysiology and lay the groundwork for developing more accurate diagnostic tools and targeted therapeutic strategies.
Authors
- Renjie Tan (ORCID: https://orcid.org/0000-0001-6087-4584)
- Jia Meng (ORCID: https://orcid.org/0000-0003-3455-205X)
- Yue Wang (ORCID: https://orcid.org/0000-0003-4671-8547)
- Wenjing Li (ORCID: https://orcid.org/0000-0002-8267-7925)
- Yina Zhang (ORCID: https://orcid.org/0000-0002-3255-3748)
- Lihong Jiang (ORCID: https://orcid.org/0000-0001-7295-4522)
- Yuechen Xing
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3389/fgene.2025.1630705
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81