Intrathecal contrast-enhanced MRI reveals an alternative route for drug delivery and brain tumor visualization
• Systemic drug delivery to brain tumors is limited by the blood-brain barrier • Targeting brain tumors via the cerebrospinal fluid is largely unexplored in humans • Intrathecal injection of an imaging tracer in a patient accumulated in the tumor • The tracer remained in the tumor’s extravascular space for more than 48 hours • We present a strategy for visualizing brain tumors and extravascular drug delivery
Authors
- Kyrre E. Emblem (ORCID: https://orcid.org/0000-0002-6580-9519)
- Geir Ringstad (ORCID: https://orcid.org/0000-0003-0919-4510)
- Einar Osland Vik-Mo (ORCID: https://orcid.org/0000-0001-8303-4123)
- Petter Brandal (ORCID: https://orcid.org/0000-0003-0259-495X)
- Per Kristian Eide (ORCID: https://orcid.org/0000-0001-6881-9280)
- Svein Are Sirirud Vatnehol (ORCID: https://orcid.org/0000-0002-7900-0534)
- Liv Cathrine Heggebø (ORCID: https://orcid.org/0000-0003-2891-9636)
- Siri Fløgstad Svensson (ORCID: https://orcid.org/0000-0002-6282-0341)
- Trygve Holck Storås
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
Publication Details
- Journal
- Cancer Letters
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.canlet.2025.218152
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00