The relationships between proinflammatory cytokines and depressive symptoms in adolescents with chronic pain
Our findings suggest that IL-1β and IL-6 play critical roles in the pain experience. Interleukin-6 is more strongly associated with physical symptoms, and IL-1β is more related to fear-avoidance.
Authors
- Emma E. Biggs (ORCID: https://orcid.org/0000-0002-0638-6931)
- Laura E. Simons (ORCID: https://orcid.org/0000-0002-3395-9483)
- Sarah Nelson (ORCID: https://orcid.org/0000-0003-4721-8712)
- Emma Gaydos (ORCID: https://orcid.org/0009-0009-4454-8303)
- Katrina Huft
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Duke University (US)
- Tilburg University (NL)
- Stanford University (US)
Publication Details
- Journal
- PAIN Reports
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1097/pr9.0000000000001365
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00