Is the Parkinson’s-associated protein TMEM175 a proton channel: Yay or nay?
The abnormal protein degradation implicated in the pathogenesis of Parkinson's disease was previously attributed to defective H+ leakage from lysosomes via TMEM175 (https://doi.org/10.1016/j.cell.2022.05.021). In this issue, Riederer et al. (https://doi.org/10.1083/jcb.202501145) demonstrate that TMEM175 is instead a K+ channel, minimally permeable to H+.
Authors
- Spencer A. Freeman (ORCID: https://orcid.org/0000-0003-3455-3714)
- Sergio Grinstein (ORCID: https://orcid.org/0000-0002-0795-4160)
Institutions
- University of Toronto (CA)
- Hospital for Sick Children (CA)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1083/jcb.202511084
- Citations
- 1
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Canadian Institutes of Health Research