Coordinated epigenetic dysregulation of CNR1 and FAAH genes drives endocannabinoid system dysfunction in anorexia nervosa
Our findings establish this bidirectional epigenetic dysregulation as a central mechanism underlying ECS dysfunction in AN, providing mechanistic insights that identify novel therapeutic targets and advance precision medicine approaches for this challenging disorder.
Authors
- Mariangela Pucci (ORCID: https://orcid.org/0000-0003-4657-6075)
- Francesca Mercante (ORCID: https://orcid.org/0000-0002-2260-5049)
- Cristina Segura‐Garcìa (ORCID: https://orcid.org/0000-0002-5756-3045)
- Carlo Cifani (ORCID: https://orcid.org/0000-0001-6180-828X)
- Marianna Rania (ORCID: https://orcid.org/0000-0001-7742-7086)
- Annalaura Sabatucci (ORCID: https://orcid.org/0000-0002-8004-2547)
- Claudio D’Addario (ORCID: https://orcid.org/0000-0002-1275-098X)
- Federica Gilardini (ORCID: https://orcid.org/0009-0009-5806-9995)
Institutions
- Università di Camerino (IT)
- University of Teramo (IT)
- Karolinska Institutet (SE)
- Magna Graecia University (IT)
- Dulbecco Telethon Institute (IT)
Publication Details
- Journal
- Journal of Eating Disorders
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s40337-025-01472-y
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00