Synergistic effects of mesenchymal stem cell secretome and Wnt10b on hair follicle regeneration in a 3D bioengineering model: a preclinical study
Our study demonstrates that the combination of PMSC-secretome and Wnt10b in a GelMA hydrogel scaffold effectively promotes hair follicle biofabrication and successful hair formation in vivo. However, the in vivo portion was limited by a small sample size (n = 3 per group), underscoring the need for larger-scale studies to confirm these findings.
Authors
- Nasser Aghdami (ORCID: https://orcid.org/0000-0001-5390-7878)
- Amir Bajouri (ORCID: https://orcid.org/0000-0001-7360-4583)
- Mohammad Ali Nilforoushzadeh (ORCID: https://orcid.org/0009-0004-1540-0557)
Institutions
- Royan Institute (IR)
- Academic Center for Education, Culture and Research (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s13287-025-04830-4
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00