Novel cosolvent systems for nifurtimox: improving solubility, trypanocidal efficacy, and stability
Cosolvent-based delivery systems enhance the solubility of nifurtimox while maintaining adequate trypanocidal activity against Trypanosoma cruzi and demonstrating acceptable stability and safety profiles. Thus, these formulations represent a promising strategy to improve the therapeutic effectiveness of nifurtimox.
Authors
- F Azcarate
- Claudio J. Salomón (ORCID: https://orcid.org/0000-0003-1599-790X)
- Esteban Carlos Serra (ORCID: https://orcid.org/0000-0001-5986-7459)
- Carlos E. Boschetti (ORCID: https://orcid.org/0000-0003-1029-958X)
- Giselle Bedogni (ORCID: https://orcid.org/0009-0007-2020-1466)
- Luca Guerra
- Romina Manarin (ORCID: https://orcid.org/0009-0009-3406-9245)
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- National University of Rosario (AR)
- Centro Científico Tecnológico - San Juan (AR)
- Centro Científico Tecnológico - Tucumán (AR)
Publication Details
- Journal
- Therapeutic Delivery
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1080/20415990.2025.2593815
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00