Antithrombotic strategies and DOAC dosing following left atrial appendage occlusion: a network meta-analysis
DOACs provide a superior safety-efficacy profile compared with other antithrombotic strategies following LAAO, significantly reducing the risks of major bleeding, thromboembolic events, and mortality. While low-dose DOACs may offer additional bleeding risk reduction without compromising efficacy, further research is warranted to confirm their role in clinical practice.
Authors
- George A. Giannakoulas (ORCID: https://orcid.org/0000-0001-7491-6319)
- James V. Freeman (ORCID: https://orcid.org/0000-0002-4614-6879)
- Athanasios Feidakis
- Apostolos Tzikas (ORCID: https://orcid.org/0000-0001-6968-2191)
- Nikolaos Fragakis (ORCID: https://orcid.org/0000-0002-7158-4950)
- Paschalis Karakasis (ORCID: https://orcid.org/0000-0002-3561-5713)
- Martin Bergmann (ORCID: https://orcid.org/0000-0002-6140-7870)
- Athanasios Samaras (ORCID: https://orcid.org/0000-0002-3404-2749)
- Ulf Landmesser (ORCID: https://orcid.org/0000-0002-0214-3203)
- Devi G. Nair (ORCID: https://orcid.org/0000-0001-8253-947X)
- Jens-Erik Nielsen-Kudsk
Institutions
- Yale New Haven Hospital (US)
- University of Cologne (DE)
- Aristotle University of Thessaloniki (GR)
- AHEPA University Hospital (GR)
- Interbalkan Medical Center (GR)
- Aarhus University Hospital (DK)
- Yale University (US)
- Humboldt-Universität zu Berlin (DE)
- Asklepios Klinik Altona (DE)
- St Bernard's Hospital (GI)
- Deutsches Herzzentrum der Charité (DE)
- Hospital Clínic de Barcelona (ES)
- Ippokrateio General Hospital of Thessaloniki (GR)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- University Hospital Cologne (DE)
- Hippocration General Hospital (GR)
Publication Details
- Journal
- European Heart Journal - Cardiovascular Pharmacotherapy
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1093/ehjcvp/pvaf078
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00