Presence of Lassa Virus RNA in Cerebrospinal Fluid Indicating Neuroinvasive Lassa Fever in Pediatric Patients From Edo State, Nigeria
LASV is frequently detected in CSF of pediatric LF patients with neurological symptoms. The virus load in CSF is usually higher than in plasma, indicating a neuroinvasive infection with active virus replication in CNS. Our findings have implications for clinical management of LF patients and drug development for LF.
Authors
- Ikponmwosa Odia (ORCID: https://orcid.org/0000-0002-9393-9898)
- Sylvanus Okogbenin (ORCID: https://orcid.org/0000-0001-7882-8316)
- Michael Ramharter (ORCID: https://orcid.org/0000-0002-9259-1885)
- H. Mueller (ORCID: https://orcid.org/0009-0009-9129-609X)
- George O. Akpede (ORCID: https://orcid.org/0000-0003-1035-4067)
- Lisa Oestereich (ORCID: https://orcid.org/0000-0003-0098-7485)
- Mette Hinrichs
- Joseph Okoeguale (ORCID: https://orcid.org/0009-0008-9909-4700)
- Cyril Erameh (ORCID: https://orcid.org/0000-0001-7783-2495)
- Thomas Olokor
- Lilian Omoyemen Akerele
- Ephraim Ogbaini-Emovon (ORCID: https://orcid.org/0000-0001-5407-1152)
- Adewale Elijah Adetunji (ORCID: https://orcid.org/0000-0003-3394-908X)
- Stephan Günther (ORCID: https://orcid.org/0000-0002-6562-0230)
- Till F. Omansen (ORCID: https://orcid.org/0000-0003-0645-9683)
- Meike Pahlmann (ORCID: https://orcid.org/0000-0001-8423-4178)
- Matthew Apeleokha
- Osahogie Isaac Edeawe (ORCID: https://orcid.org/0000-0001-7424-8832)
- Rita Esumeh
- Chris Hoffmann (ORCID: https://orcid.org/0000-0002-5606-7234)
- Imonifome Frank Onyeke
- Jonas Müller
- Danny Asogun (ORCID: https://orcid.org/0000-0001-6811-9268)
- Sheila Ojor Ileli
- Ujiagbe Moses Aiterebhe
- Reuben Eifediyi (ORCID: https://orcid.org/0009-0007-7877-3045)
- Donatus I. Adomeh
- Kelly Iraoyah
- Ifeanyi Henry Onyerikam
- Juliet Oemhenze Idialu-Eigbobo
- Chukwuemeka Ogbuinya Ugadu
- Christiana Ngozi Ekuma
- Ehisuan Ehiaghe
- Ebo Benevolence Ohomoime
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- German Center for Infection Research (DE)
- Irrua Specialist Teaching Hospital (NG)
- Ambrose Alli University (NG)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1093/infdis/jiaf547
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00