<i>Mapping cardiac drug transport: In vitro</i> assessment of cardiac P-glycoprotein function with [18F]MC225 by using µ-engineered heart tissues
[<sup>18</sup>F]MC225 effectively evaluates and measures cardiac P-gp function in µ-EHTs on the heart-on-chip platform. This research sets the stage for future studies using P-gp function to evaluate the efficacy and safety of novel cardiovascular drugs using µ-EHTs.
Authors
- Riemer H. J. A. Slart (ORCID: https://orcid.org/0000-0002-5565-1164)
- Robert C. J. J. Passier (ORCID: https://orcid.org/0000-0003-4312-9296)
- Chantal Kwizera
- Pascalle Mossel (ORCID: https://orcid.org/0000-0002-1526-6923)
- Andries D. van der Meer (ORCID: https://orcid.org/0000-0002-8761-4077)
- Maureen Dannenberg (ORCID: https://orcid.org/0009-0004-5896-992X)
- Inês F. Antunes (ORCID: https://orcid.org/0000-0002-8003-5291)
- Gert Luurtsema (ORCID: https://orcid.org/0000-0001-8599-8129)
- Jürgen W. A. Sijbesma (ORCID: https://orcid.org/0000-0002-8878-2355)
- Zeyu Cai (ORCID: https://orcid.org/0000-0002-2852-5090)
- Verena Schwach (ORCID: https://orcid.org/0000-0003-1831-7412)
- Lu Cao (ORCID: https://orcid.org/0000-0002-1847-068X)
- Wanling Liu (ORCID: https://orcid.org/0000-0001-7159-5759)
Institutions
- Leiden University (NL)
- University Medical Center Groningen (NL)
- University of Applied Sciences Leiden (NL)
- Leiden University Medical Center (NL)
- University of Twente (NL)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1093/ehjopen/oeaf150
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council