CAND1 mediates CUL7-dependent HER2 protein stability to drive breast cancer progression
In summary, this study highlights the critical role of CAND1 in regulating HER2 ubiquitination and suggests a potential therapeutic strategy for patients with HER2-positive breast cancer.
Authors
- Hongbiao Huang (ORCID: https://orcid.org/0000-0002-9873-0559)
- Yuanlin Chen
- Xiaoyue He (ORCID: https://orcid.org/0000-0003-3582-4539)
- Yuning Liao (ORCID: https://orcid.org/0000-0003-0343-1933)
- Jiangyu Zhang (ORCID: https://orcid.org/0000-0003-1714-3684)
- Mengfan Tang
- Xiaohong Xia (ORCID: https://orcid.org/0000-0003-2219-1162)
Institutions
- Guangzhou Medical University Cancer Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s13058-025-02158-8
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province