Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

The overall HBsAg clearance rate with Peg-IFNα-2b retreatment was 20.74% (28/135). The RHCP-S model identifies optimal retreatment candidates (≥ 110 points) with 80.95% clearance probability, associated with the absence of combination NA therapy during initial treatment, greater initial HBsAg decline, longer intervals, and lower retreatment HBsAg.

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Publication Details

Journal
World Journal of Gastroenterology
Published
2025-11-27
DOI
https://doi.org/10.3748/wjg.v31.i44.112719
Primary Topic
Hepatitis B Virus Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

World Journal of Gastroenterology
Hepatitis B Virus Studies
article

Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

article en

Abstract

The overall HBsAg clearance rate with Peg-IFNα-2b retreatment was 20.74% (28/135). The RHCP-S model identifies optimal retreatment candidates (≥ 110 points) with 80.95% clearance probability, associated with the absence of combination NA therapy during initial treatment, greater initial HBsAg decline, longer intervals, and lower retreatment HBsAg.

World Journal of GastroenterologyVol. 31(44)
Tianjin Third Central Hospital (CN), Tianjin Medical University (CN)
Openalex Percentile: Top 52%
Hepatitis B Virus Studies
DOIOpen Access PDFOpenAlex
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Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B · World Journal of Gastroenterology (2025) | TGRS Research Map | TGRS