Transplanting the unexpected: a case report of a heart allograft with wild-type transthyretin cardiac amyloid

This is the first case report of a patient that inadvertently received an allograft with cardiac amyloidosis and provides insight into the natural history of this rare clinical scenario. Based on serial imaging and post-mortem histopathologic analysis, it was clear that there was progression of the underlying cardiac amyloidosis post-transplantation. We hypothesize that this occurred through the process of <i>amyloid seeding.</i> This case highlights the unique clinical and histopathologic findings of cardiac amyloidosis as well as the nuances regarding donor heart selection for transplantation.