Clinical Significance of Fractional Exhaled Nitric Oxide (FeNO) Measurements in Juvenile Idiopathic Inflammatory Myopathy‐Associated Interstitial Lung Disease

FeNO correlates with impaired lung function in JIIM-associated ILD and thus shows considerable potential as a noninvasive biomarker to differentiate ILD in pediatric JIIM patients. Our results suggest that integrating FeNO measurements into clinical practice could improve early detection, facilitate timely intervention, and enhance clinical management. Importantly, this study is the first to specifically investigate the clinical utility of FeNO in JIIM patients with ILD. Further large-scale, prospective studies are warranted to validate the role of FeNO in predicting disease progression and therapeutic decisions.

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Publication Details

Journal
Pediatric Pulmonology
Published
2025-11-26
DOI
https://doi.org/10.1002/ppul.71409
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
Field-Weighted Citation Impact
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article

Clinical Significance of Fractional Exhaled Nitric Oxide (FeNO) Measurements in Juvenile Idiopathic Inflammatory Myopathy‐Associated Interstitial Lung Disease

Aybüke Gunalp, Ayşe Ayzıt Kılınç, Ayşe Kalyoncu Uçar, Berrak Öztosun et al.
Pediatric Pulmonology
Inflammatory Myopathies and Dermatomyositis
article

Clinical Significance of Fractional Exhaled Nitric Oxide (FeNO) Measurements in Juvenile Idiopathic Inflammatory Myopathy‐Associated Interstitial Lung Disease

Aybüke Gunalp, Ayşe Ayzıt Kılınç, Ayşe Kalyoncu Uçar, Berrak Öztosun, Sebuh Kuruğoğlu, Azer Kılıç Başkan, Ozgur Kasapcopur
article en

Abstract

FeNO correlates with impaired lung function in JIIM-associated ILD and thus shows considerable potential as a noninvasive biomarker to differentiate ILD in pediatric JIIM patients. Our results suggest that integrating FeNO measurements into clinical practice could improve early detection, facilitate timely intervention, and enhance clinical management. Importantly, this study is the first to specifically investigate the clinical utility of FeNO in JIIM patients with ILD. Further large-scale, prospective studies are warranted to validate the role of FeNO in predicting disease progression and therapeutic decisions.

Pediatric PulmonologyVol. 60(12)
Istanbul University-Cerrahpaşa (TR)
Openalex Percentile: Top 52%
Inflammatory Myopathies and Dermatomyositis
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