Dysregulation of Pulpitis Progression Through Modulation of the lncRNA ITGB2-AS1 /miR-1224-5p Axis
ITGB2-AS1 exhibits high diagnostic value for pulpitis patients and holds promise as a novel diagnostic biomarker. Knocking down ITGB2-AS1 targets miR-1224-5p expression, mitigates cellular damage, and restores cellular vitality, thereby potentially slowing pulpitis progression. This establishes a theoretical foundation for positioning ITGB2-AS1 as a future therapeutic target for pulpitis.
Authors
- Dongmei Lv
- Jie Xu (ORCID: https://orcid.org/0000-0002-5960-9174)
- Changyong Yuan (ORCID: https://orcid.org/0000-0002-3795-134X)
- Lina Huang
Institutions
- Xuzhou Medical College (CN)
- Peking University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1016/j.identj.2025.104027
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00