Functional connectivity changes are associated with disability progression in multiple sclerosis: a longitudinal fMRI study
FC increases appear to reflect compensatory mechanisms in low-disability pwMS, while in more disabled patients, FC alterations likely represent maladaptive responses. These findings support resting-state FC as a biomarker for monitoring disease progression and treatment response in MS.
Authors
- Massimo Filippi
- Riccardo Tappa Brocci
- Riccardo Maria Borgo (ORCID: https://orcid.org/0009-0002-9612-4579)
- Claudia Piervincenzi (ORCID: https://orcid.org/0000-0002-7732-2062)
- Elena Barbuti (ORCID: https://orcid.org/0000-0002-0450-7699)
- Silvia Tommasin (ORCID: https://orcid.org/0000-0001-9088-7968)
- Alvino Bisecco (ORCID: https://orcid.org/0000-0002-7202-4445)
- Nicola De Stefano (ORCID: https://orcid.org/0000-0003-4930-7639)
- Paola Valsasina (ORCID: https://orcid.org/0000-0001-5390-2655)
- Rosa Cortese (ORCID: https://orcid.org/0000-0002-9803-7914)
- Nikolaos Petsas (ORCID: https://orcid.org/0000-0001-7150-9697)
- Viola Baione (ORCID: https://orcid.org/0000-0001-7895-7767)
- Patrizià Pantano (ORCID: https://orcid.org/0000-0001-9659-8294)
- Federica Satriano (ORCID: https://orcid.org/0009-0005-5891-7625)
- Maria Laura Stromillo
- Fabrizio Esposito (ORCID: https://orcid.org/0000-0002-5099-9786)
- Loredana Storelli (ORCID: https://orcid.org/0000-0002-4979-613X)
- Elisabetta Pagani (ORCID: https://orcid.org/0000-0002-1850-1175)
- Nicolò Tedone (ORCID: https://orcid.org/0000-0002-2065-9764)
- Costanza Giannì (ORCID: https://orcid.org/0000-0002-4018-169X)
- Alessandro d’Ambrosio (ORCID: https://orcid.org/0000-0001-8582-4874)
- Carlo Pozzilli (ORCID: https://orcid.org/0000-0002-6360-4798)
- Maria Assunta Rocca (ORCID: https://orcid.org/0000-0003-2358-4320)
- Paolo Preziosa (ORCID: https://orcid.org/0000-0002-7826-0019)
- Valentina Rippa
- Antonio Gallo (ORCID: https://orcid.org/0000-0002-4045-3237)
- Abhineet Ojha
- Stefania Sala
Institutions
- University of Siena (IT)
- Vita-Salute San Raffaele University (IT)
- Istituto Neurologico Mediterraneo (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1007/s00415-025-13515-0
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Fondazione Italiana Sclerosi Multipla
- Università degli Studi di Siena
- Sapienza Università di Roma