Bone marrow aspirate Cit-H3 was identified as a novel biomarker of minimal residual disease in neuroblastoma
This study demonstrates a significant correlation between NETs and MRDs, and found a positive correlation between bone marrow MRD<sup>+</sup> and the indicators of IL-2, IL-6, and NSE, as well as a positive correlation with bone marrow neutrophils. And Cit-H3 was identified as a new biomarker and found a positive correlation between Cit-H3 and bone marrow MRD<sup>+</sup>.
Authors
- Lin Liu (ORCID: https://orcid.org/0000-0001-9881-6830)
- Yuge Ni (ORCID: https://orcid.org/0000-0001-5162-6562)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Tiantian She
- Baocheng Gong (ORCID: https://orcid.org/0000-0001-5236-3506)
- Chen Huang (ORCID: https://orcid.org/0000-0001-6094-1812)
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0002-3807-1248)
- Chong Chen (ORCID: https://orcid.org/0000-0003-1824-6116)
- Mengxia Zhang (ORCID: https://orcid.org/0000-0002-7908-5072)
- Xiang Wang (ORCID: https://orcid.org/0000-0001-5433-9905)
Institutions
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12885-025-15305-3
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00