Novel <scp> <i>SOS1</i> </scp> Mutations Associated With Hereditary Gingival Fibromatosis and Dual‐Gated Model for <scp>SOS1</scp> Activation
Our study identified two novel SOS1 mutations, c.3262dupA/p.Thr1088fs and c.1523A>G/p.Asn508Ser, in two unrelated Han Chinese families with non-syndromic HGF. A novel "Dual-Gated Model" was proposed to elucidate the full activation process of wild-type and truncated SOS1. We extended the mutational spectrum of SOS1 in non-syndromic HGF and provided new insights on the molecular mechanism of pathogenesis.
Authors
- Nuo Xu (ORCID: https://orcid.org/0000-0002-5451-1565)
- Qian Gao (ORCID: https://orcid.org/0000-0001-5300-8012)
- Zhuan Bian (ORCID: https://orcid.org/0000-0002-8035-4276)
- Xiaona Song
- Kai S. Yang (ORCID: https://orcid.org/0000-0002-1890-4169)
- Chengcan Yang (ORCID: https://orcid.org/0000-0002-4211-9478)
Institutions
- Wuhan University (CN)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1111/jop.70080
- Primary Topic
- Oral and gingival health research
- Type
- article
- Field-Weighted Citation Impact
- 0.00