Gymnemantoside A Ameliorates Steroid‐Induced Skeletal Muscle Atrophy via Bridging Glucocorticoid and Insulin Receptor Signalling
A newly identified bioactive compound gymnemantoside A, isolated from Gymnema inodorum, was structurally characterized and showed efficacy in Dex-induced muscle atrophy models. Gymnemantoside A produces anti-muscle atrophy effects by a hitherto unreported mechanism: modulation of the insulin receptor kinase domain and activation of downstream signalling, alongside competitive inhibition of the glucocorticoid receptor, which has been implicated in multiple forms of skeletal muscle wasting.
Authors
- Won Keun Oh (ORCID: https://orcid.org/0000-0003-0761-3064)
- Thi‐Phuong Doan (ORCID: https://orcid.org/0000-0001-8662-1251)
- Darren R. Williams (ORCID: https://orcid.org/0000-0003-2555-3069)
- Seri Choi (ORCID: https://orcid.org/0000-0002-0295-7370)
- Sanghoon Lee (ORCID: https://orcid.org/0000-0002-1265-3821)
- Eun Jin Park (ORCID: https://orcid.org/0000-0002-5478-2074)
- Hyun‐Jun Kim (ORCID: https://orcid.org/0000-0001-9254-394X)
- Jin‐Pyo An (ORCID: https://orcid.org/0000-0002-7143-9497)
- Da‐Woon Jung (ORCID: https://orcid.org/0000-0001-6005-0833)
- Kyoung‐Hwan Joo
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- Gwangju Institute of Science and Technology (KR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1002/jcsm.70118
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81