WDR4-mediate tRNA m7G modification to promote mitophagy and browning of white adipose tissue for ameliorating obesity in male mice
WDR4 promotes adipocyte browning by enhancing BMP8B translation through tRNA m<sup>7</sup>G modification, revealing a novel m<sup>7</sup>G epitranscriptomic mechanism with therapeutic potential for obesity.
Authors
- Zhigu Liu
- Yonghui Li (ORCID: https://orcid.org/0000-0003-4320-0806)
- Wen Xu (ORCID: https://orcid.org/0000-0002-8258-2707)
- Panwei Mu (ORCID: https://orcid.org/0000-0001-5413-6876)
- Yanling Yang (ORCID: https://orcid.org/0000-0001-8246-1756)
- Chaofan Wang (ORCID: https://orcid.org/0000-0001-5292-5564)
- Beisi Lin (ORCID: https://orcid.org/0000-0001-8542-8265)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Adipocyte
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1080/21623945.2025.2588888
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00