A cigarette compound-induced tumor microenvironment promotes sorafenib resistance in hepatocellular carcinoma via the 14-3-3η-modified tumor-associated proteome
A cigarette compound-formed tumor microenvironment resisted HCC to sorafenib by locking the adaptor protein 14-3-3η in a constitutively active state. This outcome provided a mechanistic rationale and a translational strategy to re-sensitize HCC patients exposed to cigarette to targeted therapy.
Authors
- Xinru Du (ORCID: https://orcid.org/0000-0002-7289-941X)
- Maoxuan Li
- Ming Jin (ORCID: https://orcid.org/0000-0002-4927-4382)
- Yu Sun (ORCID: https://orcid.org/0000-0002-9819-3263)
- Chengwu Tang
- Zhihui Feng (ORCID: https://orcid.org/0000-0003-1281-766X)
- Ming Lü
- Chi Zhang (ORCID: https://orcid.org/0000-0002-9188-6307)
- Yuan Li (ORCID: https://orcid.org/0000-0002-5186-6360)
- Hongquan Zhang (ORCID: https://orcid.org/0000-0001-8193-0899)
- Xue Dong (ORCID: https://orcid.org/0000-0002-6213-2821)
- Xiaojun Yang (ORCID: https://orcid.org/0000-0001-9833-6415)
- Na Dong (ORCID: https://orcid.org/0000-0002-3292-3091)
- Shuoke Duan
- Sisi Song
- Qinliang Mo
Institutions
- Fujian Medical University (CN)
- Huzhou Normal University (CN)
- Yili Friendship Hospital (CN)
- Ministry of Education (KR)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Third People's Hospital of Huzhou (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1097/cm9.0000000000003851
- Citations
- 1
- Primary Topic
- 14-3-3 protein interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.81