The influence of endometrial thickness on clinical pregnancy outcomes in early-follicular long-acting and midluteal short-acting GnRH agonist long protocols: a large retrospective study
The study indicates that in the early-follicular long-acting GnRH agonist protocol, increasing EMT up to 10.6 mm is associated with improved clinical pregnancy and live birth rates, with no further benefits observed beyond this threshold. In contrast, the midluteal short-acting GnRH agonist long protocol exhibits a continuous positive relationship between EMT and pregnancy outcomes. Overall, the early-follicular long-acting protocol offers better clinical outcomes for patients with EMT less than 15 mm, while both protocols perform similarly when EMT is ≥15 mm.
Authors
- Huijuan Kong (ORCID: https://orcid.org/0000-0003-0535-2438)
- Zhiqin Bu (ORCID: https://orcid.org/0000-0003-2343-3493)
- Guidong Yao (ORCID: https://orcid.org/0000-0002-7174-9989)
- Chen Wang (ORCID: https://orcid.org/0000-0001-7857-5435)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-0077-7341)
- Jun Zhai (ORCID: https://orcid.org/0000-0001-9566-865X)
- Liping Han (ORCID: https://orcid.org/0009-0005-9100-1563)
- Wei Dai (ORCID: https://orcid.org/0000-0003-3316-3570)
- Yihong Peng (ORCID: https://orcid.org/0000-0002-3603-8014)
- Congying Yang
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fendo.2025.1637587
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China