cAMP-MFN2 signaling suppresses cochlear cell senescence and age-related hearing loss
Our study reveals a critical protective role for the cAMP-MFN2 axis in auditory aging by suppressing cellular senescence. These findings identify this axis as a novel and promising therapeutic target for the treatment of age-related hearing loss.
Authors
- H. Chen (ORCID: https://orcid.org/0000-0003-1514-7016)
- Yu Liu (ORCID: https://orcid.org/0000-0002-7968-0162)
- Shuyong Qin (ORCID: https://orcid.org/0009-0000-4572-0704)
- Qi Li (ORCID: https://orcid.org/0000-0001-5409-0249)
- Jinyuan Cao
- Jie Cui
- Zhongwu Su (ORCID: https://orcid.org/0000-0003-0758-9308)
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1715738
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province