Enhanced therapeutics of cabazitaxel via polycarboxylate conjugation: improved solubility, safety, and antitumor efficacy
This study establishes polycarboxylate conjugation as a promising strategy for developing safer and more effective chemotherapeutic agents through rational molecular design, successfully decoupling antitumor efficacy from systemic toxicity.
Authors
- Na Zhu (ORCID: https://orcid.org/0000-0001-6386-4699)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-0159-9062)
- Xueming Wang (ORCID: https://orcid.org/0000-0001-5860-9829)
- Tianjun Liu (ORCID: https://orcid.org/0000-0002-4661-4417)
- Lina Mao
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1680710
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundamental Research Funds for the Central Universities