LL37-driven mast cell degranulation and inflammation in rosacea via TLR2/JAK2/STAT3 axis
These findings collectively demonstrate that LL37 drives mast cell activation and degranulation in rosacea pathogenesis via TLR2/JAK2/STAT3 pathway activation, while ruxolitinib effectively suppresses this signaling axis. This study provides novel mechanistic insights and therapeutic strategies for rosacea management.
Authors
- Huiping Fan (ORCID: https://orcid.org/0000-0001-8424-2792)
- Weiyuan Ma (ORCID: https://orcid.org/0000-0002-4549-3166)
- Jiayun Liu (ORCID: https://orcid.org/0009-0001-9048-3709)
- Rui Sun (ORCID: https://orcid.org/0000-0002-3205-7509)
- Mogen Zhang
- David Zhang (ORCID: https://orcid.org/0000-0002-5027-5286)
- Xu Chen (ORCID: https://orcid.org/0000-0001-9506-1815)
- Xiaojin Li (ORCID: https://orcid.org/0000-0002-6525-8585)
- Qingsong Ma
Institutions
- Weifang Medical University (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1672021
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00