Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection
This study highlights the distinct biological features of CD4⁺ and CD8⁺ TIL populations within the tumor microenvironment that can be preserved using a minimally expanded TIL approach. The observed associations between IHC patterns, T cell subset composition, cytotoxic potential, and TCR repertoire diversity help identify which biopsy regions yield TILs with greater therapeutic potential, thus providing guidance for TIL selection in immunotherapy.
Authors
- Vicente Peg (ORCID: https://orcid.org/0000-0002-5203-6166)
- Laia Garrigós
- Maitane Faus
- Mercè Martı́ (ORCID: https://orcid.org/0000-0002-1846-0043)
- Gonzalo Lázaro
- Javier Cortés (ORCID: https://orcid.org/0000-0001-7623-1583)
- V. Marco (ORCID: https://orcid.org/0000-0002-3115-7567)
- Andrea Aran (ORCID: https://orcid.org/0000-0002-9036-2085)
- José Manuel Pérez-García (ORCID: https://orcid.org/0000-0003-4238-2046)
Institutions
- Hebron University (PS)
- Universitat Autònoma de Barcelona (ES)
- Hospital Clínico San Carlos (ES)
- MedSIR (Spain) (ES)
- Hospital Quirónsalud Barcelona (ES)
- Vall d'Hebron Hospital Universitari (ES)
- International Breast Cancer Study Group (CH)
- Universidad Europea de Madrid (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1699262
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00