Peptide-modified phase-transition nanoparticles co-deliver FTO siRNA and Ce6 for sonodynamic metabolism-immunotherapy of melanoma
This study demonstrated that si-Ce6@tLyP-1 NPs serve as a platform for targeted the tumor site and efficiently deliver siFTO and Ce6. The realization of FTO inhibition combined with SDT provides an effective treatment strategy for the treatment of melanoma.
Authors
- Junting Ren (ORCID: https://orcid.org/0000-0002-7492-6864)
- Haodong Li (ORCID: https://orcid.org/0000-0003-0532-9481)
- Xiaoping Leng (ORCID: https://orcid.org/0000-0001-8883-8884)
- Peng Zhao (ORCID: https://orcid.org/0000-0001-6216-3858)
- Jianfeng Chen (ORCID: https://orcid.org/0000-0002-4927-602X)
- Xintong Li (ORCID: https://orcid.org/0000-0003-2758-6032)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-6245-7418)
- Yapeng Li (ORCID: https://orcid.org/0000-0003-3292-0824)
- Pan Li (ORCID: https://orcid.org/0000-0002-0316-0355)
- Rui Tang (ORCID: https://orcid.org/0000-0002-2734-1003)
- Li Wan (ORCID: https://orcid.org/0000-0003-1004-654X)
- Weinan Sun (ORCID: https://orcid.org/0000-0002-8101-8354)
- YU Wei-dong (ORCID: https://orcid.org/0000-0002-3767-5066)
- Ping Sun (ORCID: https://orcid.org/0000-0002-5487-9503)
- Yunpeng Wang (ORCID: https://orcid.org/0009-0001-6942-2645)
- Zhuo Wang (ORCID: https://orcid.org/0009-0002-2315-8604)
Institutions
- Harbin Medical University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Heilongjiang International University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12951-025-03872-3
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00