When Fitness Turns Fatal: A Case of Severe Rhabdomyolysis in a 20-Year-Old Male

Exertional rhabdomyolysis (ER) is a potentially life-threatening condition caused by intense or prolonged physical activity, leading to skeletal muscle injury and leakage of intracellular components into the circulation. Although commonly recognized in athletes and military recruits, it may also occur in previously healthy individuals undertaking unaccustomed high-intensity exercise. We report a 20-year-old male with no significant medical history who presented with muscle soreness, dysuria, and dark urine following increased gym activity. Laboratory studies demonstrated extremely elevated creatine kinase (CK) levels consistent with severe ER; however, kidney function remained entirely normal despite the markedly elevated CK, a feature that makes this case clinically distinctive. Prompt recognition and aggressive intravenous fluid resuscitation resulted in full recovery. This case provides educational value by emphasizing that even "sky-high" CK levels do not invariably lead to renal impairment when ER is rapidly identified and managed, underscoring the importance of early intervention and careful monitoring in individuals engaging in unsupervised intense exercise.

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Journal
Cureus
Published
2025-11-25
DOI
https://doi.org/10.7759/cureus.97811
Primary Topic
Muscle and Compartmental Disorders
Type
article
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0.00
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article

When Fitness Turns Fatal: A Case of Severe Rhabdomyolysis in a 20-Year-Old Male

Aung Naing, S Ahmed, Farah Shahid, Wardah Tariq et al.
Cureus
Muscle and Compartmental Disorders
article

When Fitness Turns Fatal: A Case of Severe Rhabdomyolysis in a 20-Year-Old Male

Aung Naing, S Ahmed, Farah Shahid, Wardah Tariq, Habeeb Kamal
article en

Abstract

Exertional rhabdomyolysis (ER) is a potentially life-threatening condition caused by intense or prolonged physical activity, leading to skeletal muscle injury and leakage of intracellular components into the circulation. Although commonly recognized in athletes and military recruits, it may also occur in previously healthy individuals undertaking unaccustomed high-intensity exercise. We report a 20-year-old male with no significant medical history who presented with muscle soreness, dysuria, and dark urine following increased gym activity. Laboratory studies demonstrated extremely elevated creatine kinase (CK) levels consistent with severe ER; however, kidney function remained entirely normal despite the markedly elevated CK, a feature that makes this case clinically distinctive. Prompt recognition and aggressive intravenous fluid resuscitation resulted in full recovery. This case provides educational value by emphasizing that even "sky-high" CK levels do not invariably lead to renal impairment when ER is rapidly identified and managed, underscoring the importance of early intervention and careful monitoring in individuals engaging in unsupervised intense exercise.

CureusVol. 17(11)
University Hospitals of Leicester NHS Trust (GB)
Openalex Percentile: Top 44%
Muscle and Compartmental Disorders
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