Computationally-directed mechanical ventilation in a porcine model of ARDS
We successfully implemented a computationally directed APRV modality on a transport ventilator, adjusting T<sub>Low</sub> based on respiratory mechanics. This study demonstrated that CD-APRV can be safely used, with the advantage of guiding expiratory duration adjustments based on physiologic feedback from the lungs.
Authors
- Gary F. Nieman (ORCID: https://orcid.org/0000-0002-4541-4472)
- David W. Kaczka (ORCID: https://orcid.org/0000-0003-4378-5242)
- Michaela C. Kollisch-Singule (ORCID: https://orcid.org/0000-0001-9422-1063)
- A. Fonseca Cruz (ORCID: https://orcid.org/0000-0001-6969-1223)
- Mark S. Baker (ORCID: https://orcid.org/0000-0001-5858-4035)
- Jacob Herrmann (ORCID: https://orcid.org/0000-0001-5046-5592)
- Dorian LeCroy
- Joshua Satalin (ORCID: https://orcid.org/0000-0002-7582-2493)
- Joshua R. Kenna
- Ben‐Gary Harvey
- Jacob Charlamb
- George Beck
- Mark Lutz
- Sarah Satalin
Institutions
- University of Iowa (US)
- Arkansas Children's Hospital (US)
- SUNY Upstate Medical University (US)
- Cornell University (US)
- University of Arkansas Medical Center (US)
- ZSX Medical (United States) (US)
- New York State College of Veterinary Medicine (US)
- State University of New York at Oswego (US)
- ZOLL Medical Corporation (United States)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fphys.2025.1602578
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- National Institutes of Health