Case Report: Nirogacestat therapy induces rapid response in a patient with refractory, life-threatening desmoid tumor
Albeit rarely lethal in general, DT can exert life-threatening danger by local infiltration into vital tissue, such as blood vessels. The presented case highlights the novel γ-secretase inhibitor nirogacestat as a highly effective therapy preventing infiltration of the right carotid artery by a remarkably refractory DT.
Authors
- Markus Herrmann (ORCID: https://orcid.org/0000-0002-3559-9899)
- Dennis Christoph Harrer (ORCID: https://orcid.org/0000-0001-7512-572X)
- Maya Niethard (ORCID: https://orcid.org/0000-0001-9170-7201)
- Felix Keil (ORCID: https://orcid.org/0000-0002-0651-5916)
- Martin Vogelhuber
- Daniel Mahr
- Sebastian Geis (ORCID: https://orcid.org/0000-0002-2718-073X)
- Matthias Grube
- Gerardo Napodano (ORCID: https://orcid.org/0009-0008-5411-0412)
- Wolfgang Herr
Institutions
- University Hospital Regensburg (DE)
- University of Regensburg (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fonc.2025.1714475
- Citations
- 1
- Primary Topic
- Soft tissue tumor case studies
- Type
- article
- Field-Weighted Citation Impact
- 1.67