Significance of a Higher-Than-Expected Resonance at a 2.02 ppm Chemical Shift on 1H-Magnetic Resonance Spectroscopy (1H-MRS) in Neuroimaging
An accentuated 2.02 ppm peak on ¹H-MRS should not be interpreted as NAA-specific without contextual correlation. The chemical shift of 2.02 ppm is a metabolite signature of the methyl protons of the N-acetyl group and provides no further information about attached moieties. The signal may arise from a wide gamut of compounds with N-acetyl groups arising from diverse biochemical substrates in metabolic, cystic, and neoplastic lesions, as elucidated. Awareness of these mimics improves diagnostic accuracy and prevents misinterpretation of spectroscopy findings.
Authors
- Shiva Shankar M P
- Richa Singh Chauhan (ORCID: https://orcid.org/0000-0003-0919-1811)
- Chandrajit Prasad (ORCID: https://orcid.org/0000-0001-6944-0926)
- Prasad B. Hanagandi (ORCID: https://orcid.org/0000-0003-3654-8329)
- Shumyla Jabeen (ORCID: https://orcid.org/0000-0002-3816-4313)
- Karthik Kulanthaivelu (ORCID: https://orcid.org/0000-0002-1585-8769)
- Maya Bhat
- Dwarakanath Srinivas
Institutions
- All India Institute of Medical Sciences Raipur (IN)
- Sri Ramachandra Institute of Higher Education and Research (IN)
- Sher-i-Kashmir Institute of Medical Sciences (IN)
- ACS Medical College and Hospital (IN)
- National Guard Health Affairs (SA)
- National Institute of Mental Health and Neurosciences (IN)
Publication Details
- Journal
- Cureus
- Published
- 2025-11-25
- DOI
- https://doi.org/10.7759/cureus.97810
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00