Combination metformin and liraglutide in PCOS: clinical efficacy in women and preclinical insights from gut microbiome modulation in rats
Metformin combined with liraglutide significantly improved metabolic and endocrine characteristics in PCOS women. The associated amelioration of gut microbiota dysbiosis in PCOS rats suggests a potential mechanistic link, which warrants verification in future clinical studies.
Authors
- Yuqing Fang
- Xuefeng Long (ORCID: https://orcid.org/0000-0003-3181-6275)
- Ling Zhang (ORCID: https://orcid.org/0000-0002-9416-6671)
- Yi Liu (ORCID: https://orcid.org/0000-0002-4403-2325)
- Yanhui Li (ORCID: https://orcid.org/0000-0002-9921-4425)
- Jingyi Li (ORCID: https://orcid.org/0000-0003-1019-7030)
- Xiaoli Wang (ORCID: https://orcid.org/0009-0001-5892-7402)
- Xiuping Wang (ORCID: https://orcid.org/0000-0003-0888-7120)
Institutions
- Wuhan Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fendo.2025.1599879
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Huazhong University of Science and Technology
- Tongji University