Exploratory spatial transcriptomic profiling of peritumoral Th2 immune polarization in HPV-positive oropharyngeal cancer
These exploratory findings suggest that peritumoral Th2-biased immunity within lymphoid structures may contribute to restraining lymphatic metastasis in HPV-positive OPC. Spatial transcriptomics may provide a high-resolution framework for investigating tumor-immune interactions and generating hypotheses for future mechanistic and clinical studies.
Authors
- Naohiro Wakisaka (ORCID: https://orcid.org/0000-0003-0909-1650)
- Makiko Moriyama‐Kita (ORCID: https://orcid.org/0000-0002-0778-3939)
- Satoru Kondo (ORCID: https://orcid.org/0000-0002-9066-0787)
- Kazuhira Endo (ORCID: https://orcid.org/0000-0002-5401-8594)
- Hisashi Sugimoto (ORCID: https://orcid.org/0000-0001-8903-4423)
- Tomokazu Yoshizaki (ORCID: https://orcid.org/0000-0002-2420-5540)
- Takayoshi Ueno (ORCID: https://orcid.org/0000-0002-8196-3532)
- Eiji Kobayashi (ORCID: https://orcid.org/0000-0001-7318-8057)
- Yosuke Nakanishi
Institutions
- Kanazawa University (JP)
- Kanazawa Medical University (JP)
- Kanazawa Medical Center (JP)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fonc.2025.1732480
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science