SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway–targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trials
In this study, treatment with monoclonal antibodies acting on the CGRP pathway showed a favorable safety profile in patients with complex clinical conditions not represented in clinical trials, with no serious adverse events observed during extended follow-up. These findings support their use in real-world clinical settings, although further studies are needed to confirm their long-term safety.
Authors
- Alicia González‐Martínez (ORCID: https://orcid.org/0000-0002-1228-1503)
- David García‐Azorín (ORCID: https://orcid.org/0000-0002-3132-1064)
- Yésica González‐Osorio (ORCID: https://orcid.org/0000-0003-1461-9798)
- Guillermo Martín-Ávila (ORCID: https://orcid.org/0000-0002-5245-2995)
- G. Latorre (ORCID: https://orcid.org/0009-0003-0168-1645)
- Jaime Rodríguez-Vico (ORCID: https://orcid.org/0000-0001-9360-5444)
- Patricia Heredia
- Alex Jaimes (ORCID: https://orcid.org/0000-0002-0890-9484)
- Antonio Sánchez‐Soblechero (ORCID: https://orcid.org/0000-0002-7098-8494)
- Ángel L. Guerrero (ORCID: https://orcid.org/0000-0001-7493-6002)
- Daniel Toledo-Alfocea (ORCID: https://orcid.org/0000-0003-3651-1614)
- Carlos Calle Caamaño (ORCID: https://orcid.org/0000-0002-2268-2466)
- Vicente González‐Quintanilla (ORCID: https://orcid.org/0000-0003-0902-3906)
- Sarai Urtiaga Valle
- Ana Beatriz Gago‐Veiga (ORCID: https://orcid.org/0000-0002-0038-3406)
- María L. Cuadrado (ORCID: https://orcid.org/0000-0001-8246-3743)
- Jorge Madera
- Marta González Salaíces
- Elisa Luque‐Buzo (ORCID: https://orcid.org/0000-0002-7983-9268)
- Andrea Gómez García
- R. Terrero Carpio
- Julio Pascual (ORCID: https://orcid.org/0000-0002-4735-7838)
- Marcos Polanco (ORCID: https://orcid.org/0009-0006-8609-7385)
- Alberto Lozano Ros
- Javier Casas Limón
- I. Fernández Lázaro
- Cristina Sanabria-Gago
Institutions
- Universidad Complutense de Madrid (ES)
- Universidad de Cantabria (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- Hospital Universitario de Torrejón (ES)
- Marqués de Valdecilla University Hospital (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Hospital Universitario 12 De Octubre (ES)
- Hospital Universitario de Getafe (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Universitario de Fuenlabrada (ES)
- Hospital Clínico Universitario de Valladolid (ES)
- Hospital Universitario Río Hortega (ES)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fneur.2025.1703876
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Instituto de Salud Carlos III
- European Regional Development Fund